Right ventricular function in patients with significant tricuspid regurgitation

Abstract Funding Acknowledgements Type of funding sources: None. Aim The aim this meta-analysis was to systematically investigate the prognostic value right ventricular (RV) function in all-comers patients with significant (at least moderate, ≥ 2+) tricuspid regurgitation (TR). Background Chronic TR imposes a volume overload RV leading progressive dilatation and dysfunction. A comprehensive assessment is paramount importance guide therapeutic management these patients; however, it remains challenging, particularly presence altered loading conditions. Methods MEDLINE, ISI Web Science, SCOPUS databases were searched for studies published up July 2022. Studies reporting data on at one echocardiographic parameter outcome included. This study designed according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) requirements. primary endpoint all-cause long-term mortality (more than year). Results Out 3,152 studies, total 10 included analytic synthesis, enrolling 3435 subjects. median follow-up our population 28 [22 – 70] months. All-cause 40% (95% confidence interval [CI]: 32–49%, p = 0.028; Figure 1). To explore potential impact effect size modifiers mortality, we performed meta-regression analysis baseline characteristics studies. At long-term, relation found between fractional area change (RV-FAC), annular plane systolic excursion (TAPSE), tissue doppler imaging velocity (TDI s’) mortality. In particular, RV-FAC associated reduced incidence [7 2,611 subjects, intercept 5.18, slope −0.15, P 0.007; 2]; whereas both TAPSE TDI s’ unsatisfactory predict [TAPSE 9 2,891 1.73, −0.12, 0.36; 5 1429 −2.06, 0.15, 0.78]. Interestingly, diabetes mellitus (DM) hyperlipidaemia an increased risk [DM 3371 −2.62, 0.09, 0.004; 6 2338 −2.91, 0.05, 0.01]. Conclusions Significant all-cause. knowledge, first demonstrate that only RV-FAC, not conventional indexes longitudinal function, correlates adverse outcomes TR.